Journal article
Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation
YC Chen, S Wijekoon, A Matsumoto, J Luo, H Kiriazis, E Masterman, G Yildiz, J Cross, AC Parslow, R Chooi, J Sadoshima, DW Greening, KL Weeks, JR McMullen
Clinical Science | PORTLAND PRESS LTD | Published : 2024
DOI: 10.1042/CS20240178
Abstract
Atrial fibrillation (AF) remains challenging to prevent and treat. A key feature of AF is atrial enlargement. However, not all atrial enlargement progresses to AF. Atrial enlargement in response to physiological stimuli such as exercise is typically benign and reversible. Understanding the differences in atrial function and molecular profile underpinning pathological and physiological atrial remodelling will be critical for identifying new strategies for AF. The discovery of molecular mechanisms responsible for pathological and physiological ventricular hypertrophy has uncovered new drug targets for heart failure. Studies in the atria have been limited in comparison. Here, we characterised m..
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Grants
Awarded by Baker Foundation
Funding Acknowledgements
This work was supported by grants from the National Heart Foundation of Australia (Vanguard) [grant numbers 105720 (to J.R.M.) and 105072 (to D.W.G.) ] ; National Health and Medical Research Council (Ideas) [grant number 2029334 (to J.R.M. and Y.C.C.) ] , and in part by the Victorian Government's Operational Infrastructure Support Program. D.W.G. is supported by the Amelia Hains Foundation, and National Health and Medical Research Council (Ideas/MRFF schemes) . K.L.W. is supported by Future Leader Fellowships from the National Heart Foundation of Australia [grant number 102539 (to K.L.W.) ] . J.R.M. was supported by a National Health and Medical Research Council Senior Research Fellowship [grant number 1078985] and Baker Fellowship (The Baker Foundation, Australia) .